Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging

Abstract A wise selection of tracers is critical for magnetic particle imaging (MPI). Most the current are based on superparamagnetic iron oxide nanoparticles (SPIONs) with a suitable coating. We prepared maghemite cores (γ-Fe 2 O 3 ) by coprecipitation Fe(II) and Fe(III) salts ammonium hydroxide followed oxidation hydrogen peroxide stabilization as an anionic ⊖ or cationic colloid ⨁ ). The were coated poly( N -(2-hydroxypropyl)methacrylamide)-co- -[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. particles characterized dynamic light scattering, transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, tested in vitro field-free point MPI scanner, compared to sodium hypochlorite commercially available Resovist®. had average diameter 8.0 nm 8.7 ); hydrodynamic was 88 nm. Zeta potential values both positively charged (+52 mV) negatively (–60 provided good colloidal stabilization. Spinel structure confirmed spectroscopy. uncoated γ-Fe yielded signal lower (by 16 %) than Resovist; ones reached % Resovist signal. Anionic higher (uncoated particles, 15 comparable (coated ones) relative substantially dispersion. Control scored weakest results. To conclude, size, narrow size distribution, stability predispose synthetized use tracer MPI. dispersion commercial tracers.